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KMID : 0605720070130020283
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Journal of the Korean Society of Biological Therapies in Psychiatry
2007 Volume.13 No. 2 p.283 ~ p.292
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Neurological Soft Signs and Frontal Executive Function in Schizophrenic Patients and Their First Degree Relatives
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Hwang Bok-Jin
Kim Jeong-Lan
Lee Sun-Woo
Chee Ik-Seung
Kim Soo-Young
Hong Sung-Gon
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Abstract
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Objectives: This study was conducted to investigate if the neurological soft signs and dysfunction of frontal execution would be a potential marker of neurodevelopmental abnormalities in individuals with schizophrenia.
Methods: We examined subjects using the Neurological Evaluation Scale(NES) and EXIT of Kims frontal executive neuropsychological test in 20 patients with schizophrenia, 20 of their first relatives, and 20 normal controls.
Results: In terms of NES, it showed significant difference in Motor Coordination and Sequencing complex motor acts(Patients≥Relatives≥Controls) and Others of NES showed more frequently in Patients than Relatives and Controls. However, there is no difference in sensory Integration among the three groups. Total score of NES were the greatest in patients with schizophrenia, first degree Relatives had intermediate score(Patients＞Relatives＞Controls) (p<.0001). In regards to the quantity test of EXIT, Stroop, Word fluency, and Figure fluency were lower in Patients and Relatives than Controls, and Recognition were the lowest in Patients. Only Recognition efficiency was significantly lower in Patients than other groups(Patients≥Relatives≥Controls). Generally, EIQ was significantly lower in Patients than Relatives and Controls. Subtest of EXIT were negatively correlated with Motor Coordination, Sequencing complex motor acts, and Others of NES.
Conclusion: Although there are a few limitations in this study, it is found that neurological soft signs have a significant correlation with frontal executive function in patients with schizophrenia and their first degree relatives and patients with schizophrenia have greater neurological soft signs and deficits of frontal execution than their relatives.
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KEYWORD
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Neurological soft signs, Frontal execution, Schizophrenia, First degree relatives
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